The Top 5 Cannabinoids
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#1 THC or Delta(9)-tetrahydrocannabinol
The most famous cannabinoid is the compound responsible for giving the "high" feeling, and is what has given cannabis it's bad reputation. Things are changing slowly for THC through medical research and through states choosing to legalize the substance for medical and recreational use. Due to its federal status as a controlled substance you can count on our products here at Karma Farma 1000 to be 100% free of THC.
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#2 CBD or Cannabidiol
With the discovery of the Endocannabinoid System 25 years ago and its role as the bodies master regulator, Cannabidiol (CBD) a cannabinoid derived from the hemp plant has proven to be a key molecule in regulating this system. Cannabidiol is non-psycoactive. How cannabidiol works is still being sorted out by scientists. It produces many beneficial effects through multiple pathways. Although cannabidiol does not bind directly with CB1 & CB2 receptors, it activates several non cannabinoid receptors and ion channels which in turn help regulate physiological functions throughout our body. Terpenes also aid in this process. While we cannot make medical claims, Broad Spectrum CBD Rich Hemp medicines are often recommended by progressive physicians in the treatment of nerve damage, psychosis, inflammatory conditions, AIDS, chronic pain, diabetes, epilepsy, cancer, depression, anxiety, bipolar disorder, bone disease and age related disorders such as alzheimers and dementia, among others.
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#3 CBC or Cannabichromene
CBC is the third most common cannabinoid which has been shown to be effective in certain treatments on its own but becomes more effective when paired with other cannabinoids. Like CBD, it is non-psychoactive and won't produce the "high" commonly associated with cannabis use. While we cannot make medical claims, research has shown it is useful in anti-inflammatory, anti-depressive, and anti-fungal treatments.
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#4 CBN or Cannabinol
As an appetite stimulant, CBN was found to be superior to THC and CBD in animal studies. While we cannot make medical claims, CBN has been shown effective for antibiotic treatment, ALS, anti-asthmatic, sedative, glaucoma, appetite stimulant, and as a pain killer.
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#5 CBG or Cannabigerol
This cannabinoid forms early in the Cannabis plant growth cycle. It is usually not very abundant and is non-psychoactive. CBG is especially an effective antimicrobial agent. While we cannot make medical claims, CBG has also been shown effective as an antibiotic, for skin/psoriasis treatment, pain relief, anti-tumor, antidepressant, tranquilizer, and as an anti-psychotic.
So, what are cannabinoids?
- A cannabinoid is one of a class of diverse chemical compounds that acts on cannabinoid receptors, also known as the endocannabinoid system in cells that alter neurotransmitter release in the brain.
- An endoncannabinoid, also called endogenous cannabinoids, are molecules made by your body. They are similar to cannabinoids, but they're produced by the body. The main endocannabinoid produced by the body is called Anandamide. Ananda, being the prefix for the Sanskrit word bliss, joy, happiness. The other main cannabinoid is called 2-Arachidonoylglycerol (2AG). It is involved in regulation of appetite, immune system and pain management.
- The endocannabinoid system is a biological system composed of endocannabinods, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the vertebra, central nervous system, peripheral nervous system, digestive, reproductive, immune, inflammatory, and many other bodily systems.
- Cannabinoid receptors known as CB1 are primarily found in the brain, central nervous system, and peripheral organs and tissues, and are the main molecular target of the endocannabinoid ligand (binding molecule) anandamide. Other receptors known as CB2 receptors are primarily found throughout the immune system. Cannabinoids, whether endo or phyto, fit into these receptor sites like a lock and key.
- A phyto-cannabinoid (plant based) is simply a cannabinoid produced within the cannabis plant. Up to 113 cannabinoids are synthesized by this amazing plant. Although THC and CBD are typically the most prominent cannabinoids, minor cannabinoids, found in small and sometimes miniscule concentrations, are found to have a synergistic effect. Minor cannabinoids, among other benefits, have been reported to support bone health and prevent bone breakdown.
- A synthetic cannabinoid is a cannabinoid synthesized in a lab and consists of one molecule.
- A CBD isolate is the cannabidiol (CBD) molecule separated (isolated) from cannabis oil.
Cannabinoid
Endoncannabinoid
Endocannabinoid System
Cannabinoid Receptors
Phyto-cannabinoid
Synthetic Cannabinoid
CBD Isolate
The Endo-Cannabinoid System
The human body actually produces its own "endogenous" cannabinoids (chemicals otherwise unique to the cannabis plant). These cannabinoids whether formed in your body or produced in the cannabis plant and consumed or applied topically fit neatly into a series of specialized receptors located throughout the human body and skin cells, with their greatest concentration in the hippocampus (which regulates memory), the cerebral cortex (cognition), the cerebellum (motor coordination), the basal ganglia (movement), the hypothalamus (appetite), and the amygdala (emotions). Cannabinoid receptors are similarly found in "every animal species down to the sponge," Dr. Donald Abrams, chief of hematology / oncology at San Francisco General Hospital.
First identified in 1992, the endocannabinoid system (ECS) consists of CB1 receptors predominantly located in the central and peripheral nervous system, connective tissues, gonads, glands, and organs; and CB2 receptors, primarily found in the immune system and also present in the spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands, and reproductive organs. These receptors are produced by the (ECS) and are stimulated and modulated by compounds called endocannabinoids that are produced naturally in the body, like anandamide (ananda is the Sanskrit word for bliss); or by ingesting botanically-based phytocannabinoids rich in Cannabidiol (CBD), the cannabis plant's best known non-psychoactive compound; or by ingesting synthetic cannabinoids produced in a laboratory. After binding to receptors in the body these endo, phyto, and synthetic cannabinoids all produce a wide range of physiological effects, altering everything from blood pressure to pain response to memory retention to appetite and even to mood elevation, but most importantly for its anti inflamatory and neuro-protective qualities , along with stimulating new nerve growth. Although cannabidiol does not directly bind with these receptors, it functions as a mediator, along with naturally occurring terpenes creating the entourage effect to aid in bringing beneficial physiological balance within the body. Think of cannabinoids as a support element along with proper diet, excercise, sleep, relaxation and spiritual well being.
"The endogenous cannabinoid system, named after the plant that led to its discovery, is perhaps the most important physiologic system involved in establishing and maintaining human health," Dr. Dustin Sulak, a leading practitioner of what some have dubbed cannabinopathic medicine, said during a lecture at the 2010 NORML convention. "In each tissue, the cannabinoid system performs different tasks," he said. "But the goal is always the same: homeostasis, the maintenance of a stable internal environment despite fluctuations in the external environment."
Think of the (ECS) system as your body's "core" operating system - a kind of central processing unit that regulates and alters the functioning of every system and keeps them in balance. The (ECS) is the master regulator of all internal systems and is involved in internal processes down to the cellular and nuclear levels. It not only regulates the production of endocannabinoids and their receptors, it manufactures all of the necessary components needed to facilitate and to breakdown and utilize the cannabinoids. Along with regulating our central nervous system as discussed above, it also regulates the endocrine system which regulates all of our glands as well as our blood. Simply put, the Endocannabinoid System is the most important system in our body and Broad Spectrum CBD Rich Hemp Oil is the molecule that brings balance. Take control of your Chemistry!
